Health & PharmaTech

Shaping the next generation of health and pharmatech

The world just got equipped with fresh AI tooling that can make sense of the seas of data flowing out of healthcare. We see huge opportunities in data infrastructure and unique analytics and AI solutions for healthcare.

Executives-in-Residence & Advisors

Frank Williams

Director, Board of Directors, former Co-founder and CEO of Evolent Health

Jeff Butler

Founder, Privia Health

Tom Peterson

CEO, Blackbird Health; co-founder & former COO, Evolent Health

Steven A. Farmer, MD PhD

former Chief Strategy Officer for Coverage at the Centers for Medicare and Medicaid Services

Matt Loper

CEO

“Every venture fund I’ve ever met has promised to add value beyond capital, but SignalFire is the first I’ve known to exceed all expectations.”*

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October 22, 2026

Why we’re betting on Warp Sciences to accelerate U.S. drug discovery

Drug discovery is limited by how fast humans can run experiments. Warp Sciences, which emerged from stealth today with $215 million, is building an automated U.S. chemistry lab that makes molecules for biopharma customers, and it uses every experiment to train AI that helps decide what to make next. Here’s why we invested.

August 11, 2026

Why we invested in Flagler: The AI-native MSK operating system

SignalFire is doubling down on Flagler Health's $50M Series B. Learn how this AI-native MSK operating system is transforming musculoskeletal care for clinics.

February 10, 2026

Why we invested in Solace: Making healthcare advocacy a standard of care

SignalFire is doubling down on Solace’s $130 million Series C. Discover how Solace uses a full-stack OS and CMS reimbursement (CHI/PIN codes) to turn healthcare advocacy into essential infrastructure, achieving 10x YoY growth and a $1 billion+ valuation.

*Portfolio company founders listed above have not received any compensation for this feedback and may or may not have invested in a SignalFire fund. These founders may or may not serve as Affiliate Advisors, Retained Advisors, or consultants to provide their expertise on a formal or ad hoc basis. They are not employed by SignalFire and do not provide investment advisory services to clients on behalf of SignalFire. Please refer to our disclosures page for additional disclosures.